Vincristine Sulfate
Vincristine sulfate is a vinca alkaloid obtained from the Madagascar periwinkle (Catharanthus roseus). It is an antineoplastic agent that blocks cell mitosis by binding to tubulin and preventing microtubule assembly. WARNING: Fatal if given by other routes. For intravenous use only.
Dosage by Body Weight
Vincristine must only be administered intravenously by experienced clinicians. Dosage is strictly individualized, usually based on Body Surface Area (BSA) or body weight for pediatric patients under 10 kg. Typical pediatric dose is 1.5 to 2 mg/m2 weekly, capped at a maximum single dose of 2 mg. For infants and children weighing 10 kg or less, dosing is often calculated at 0.05 mg/kg weekly.
- Body Weight
- Below 5 kg
- Dose
- 0.05 mg/kg
- Frequency
- Once weekly
- Tracking Notes
- Strictly administered intravenously by pediatric oncology specialists. Highly toxic; dose requires precise calculation.
- Body Weight
- 5-7 kg
- Dose
- 0.05 mg/kg
- Frequency
- Once weekly
- Tracking Notes
- For patients weighing 10 kg or less, weight-based dosing (0.05 mg/kg) is preferred over BSA-based dosing to prevent toxicity.
- Body Weight
- 8-10 kg
- Dose
- 0.05 mg/kg
- Frequency
- Once weekly
- Tracking Notes
- Weight-based dosing (0.05 mg/kg) is standard for this range to avoid chemotherapy overdose.
- Body Weight
- 11-15 kg
- Dose
- 1.5 mg/m²
- Frequency
- Once weekly
- Tracking Notes
- Dosed using Body Surface Area (BSA). Maximum single dose limit is capped at 2 mg.
- Body Weight
- 16-20 kg
- Dose
- 1.5 mg/m²
- Frequency
- Once weekly
- Tracking Notes
- Dosed using Body Surface Area (BSA). Maximum single dose limit is capped at 2 mg.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 0.05 mg/kg | Once weekly | Strictly administered intravenously by pediatric oncology specialists. Highly toxic; dose requires precise calculation. |
| 5-7 kg | 0.05 mg/kg | Once weekly | For patients weighing 10 kg or less, weight-based dosing (0.05 mg/kg) is preferred over BSA-based dosing to prevent toxicity. |
| 8-10 kg | 0.05 mg/kg | Once weekly | Weight-based dosing (0.05 mg/kg) is standard for this range to avoid chemotherapy overdose. |
| 11-15 kg | 1.5 mg/m² | Once weekly | Dosed using Body Surface Area (BSA). Maximum single dose limit is capped at 2 mg. |
| 16-20 kg | 1.5 mg/m² | Once weekly | Dosed using Body Surface Area (BSA). Maximum single dose limit is capped at 2 mg. |
Formulation
Purpose
Used in combination chemotherapy for the treatment of acute lymphocytic leukemia (ALL), Hodgkin's lymphoma, non-Hodgkin's lymphoma, Wilms' tumor, neuroblastoma, and rhabdomyosarcoma.
Generic Name
Vincristine SulfateBranded Drug Names
Vincristine Sulfate is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.